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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/81326
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/81326


    Title: Delayed extinction and stronger drug-primed reinstatement of methamphetamine seeking in rats prenatally exposed to morphine
    Authors: Liao, Ruey-Ming
    廖瑞銘
    Shen, Ying-Ling
    Chen, Shao-Tsu
    Chan, Tzu-Yi
    Hung, Tsai-Wei
    Tao, Pao-Luh
    Contributors: 心理系
    Keywords: Conditioned place preference;Extinction;Methamphetamine;Progressive ratio;Reinstatement;Self-administration
    Date: 2016-02
    Issue Date: 2016-02-18 15:58:59 (UTC+8)
    Abstract: Prenatal morphine (PM) affects the development of brain reward system and cognitive function. The present study aimed to determine whether PM exposure increases the vulnerability to MA addiction. Pregnant Sprague-Dawley rats were administered saline or morphine during embryonic days 3–20. The acquisition, extinction and reinstatement of methamphetamine (MA) conditioned place preference (CPP) and intravenous self-administration (SA) paradigms were assessed in the male adult offspring. There was no difference in the acquisition and expression of MA CPP between saline- and PM-exposed rats, whereas PM-exposed rats exhibited slower extinction and greater MA priming-induced reinstatement of drug-seeking behavior than controls. Similarly, MA SA under progressive ratio and fixed ratio schedules was not affected by PM exposure, but PM-exposed rats required more extinction sessions to reach the extinction criteria and displayed more severe MA priming-, but not cue-induced, reinstatement. Such alterations in extinction and reinstatement were not present when PM-exposed rats were tested in an equivalent paradigm assessing operant responding for food pellets. Our results demonstrate that PM exposure did not affect the association memory formation during acquisition of MA CPP or SA, but impaired extinction learning and increased MA-primed reinstatement in both tasks. These findings suggest that the offspring of women using morphine or heroin during pregnancy might predict persistent MA seeking during extinction and enhanced propensity to MA relapse although they might not be more susceptible to the reinforcing effect of MA during initiation of drug use.
    Relation: Neurobiology of Learning and Memory, 128, 56-64
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1016/j.nlm.2015.12.002
    DOI: 10.1016/j.nlm.2015.12.002
    Appears in Collections:[心理學系] 期刊論文

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