English  |  正體中文  |  简体中文  |  Post-Print筆數 : 11 |  Items with full text/Total items : 88987/118697 (75%)
Visitors : 23578090      Online Users : 231
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 學位論文 >  Item 140.119/54794
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/54794


    Title: 美沙冬使用者抑制缺損初探
    Inhibitory deficits of methadone users
    Authors: 郭綺苑
    Kuo,Chi Yuan
    Contributors: 許文耀
    郭綺苑
    Kuo,Chi Yuan
    Keywords: 美沙冬
    注意力偏誤
    彈性認知轉換
    海洛因
    抑制缺損
    Go/No-Go
    cognition flexibility
    methadone
    heroin
    attentional bias
    inhibitory deficits
    Go/No-Go
    Date: 2011
    Issue Date: 2012-10-30 11:45:53 (UTC+8)
    Abstract:   本研究的主要目的在於探討美沙冬的使用者是否具有抑制控制能力缺損、對海洛因相關刺激是否具有注意力偏誤,以及是否有彈性認知轉換能力上的問題。
    研究使用的是Noel等人(2005,2007)發展出來的Go/No-Go作業,並使用海洛因圖片與中性圖片為作業刺激,分別測量受試者在作業中的反應正確率、反應遺漏數、反應犯錯數、平均反應時間、決定偏誤與區辨度,並且使用依賴嚴重度量表,以了解受試者對海洛因的依賴嚴重度與Go/No-Go作業各指標之間的相關。

      美沙冬組樣本選取自八里療養院土城門診部之接受美沙冬治療者,共17人,經由網路招募之健康控制組十九人,受試者一共三十六人。共變數分析之結果顯示在Go/No-Go作業的正確率、遺漏數、區辨度和決定偏誤等指標上,發現組別與情境轉換之交互作用,顯示使用美沙冬之受試者具有彈性認知能力上的缺損,因此在有轉換的區段之中,無法快速地適應新的作答規則。此外,Go/No-Go作業結果未發現美沙冬使用者之抑制缺損與對海洛因相關圖片之注意力偏誤之現象。

      依賴嚴重度與Go/No-Go作業的指標相關研究則發現,其依賴嚴重度越高,其在非轉換情境中對海洛圖片的犯錯數越低、決定偏誤越高,顯示美沙冬使用者似乎在沒有情境轉換的區段中,會將其注意力資源分配在海洛因圖片上,忽略非海洛因圖片,顯示其注意力較具選擇性。
    The goal of this study is to explore the inhibitory deficits、attentional bias towards heroin-related cues and cognition flexibility of current methadone users. The Go/No-go task used here was previously developed by Noel et al. (2005, 2007). Heroin-related pictures and neural pictures were presented as targets or non-targets. Accuracy rate、omission、commission、average reaction time、decision bias(C) and discrimination (d’) were being measured individually. The relation between the severity of heroin dependence and task performance was also investigated.

    The 17 subjects in methadone group were currently methadone maintenance treatment patients from Bali psychiatric center, and the 19 control group subjects without a drug using history were recruited by internet advertisement. The covariance analysis revealed interactions of group and shift/non-shift condition on accuracy rate、omission、decision bias(C) and discrimination (d’), indicating a cognitive flexibility deficits in methadone users. They had difficulty adapting to new rules in shifting conditions. No inhibitory deficits or attentional bias were found so far in this study.

    The relation between heroin dependence and Go/No-go task performance revealed that the more dependent the methadone subjects were, the less commission errors they made, the higher decision bias score they got towards heroin pictures in non-shifting conditions. It seemed that the methadone users were prone to allocate more attention resource to heroin-related pictures in non-shifting conditions, suggesting a more selective attention process.
    Reference: 中文部份
    行政院衛生署管制藥品管理局(2011)。100年藥物濫用案件暨檢驗統計資料。台北市,行政院衛生署。

    行政院衛生署疾病管制局(2011)。替代治療月報。台北市,行政院衛生署。

    行政院衛生署疾病管制局(2008)。HIV/AIDS統計月報表。台北市,行政院衛生署。

    法務部(2011)。毒品案件摘要統計分析。台北市,法務部。

    美國疾病控制及預防中心(Centers for Disease Control and Prevention)及教育發展學院(Academy for Educational Development)www.cdc.gov/idu
    www.healthstrategies.org/pubs/pubications.htm

    陳乃釧、楊延壽、李之徽。美沙冬替代療法。基層醫學,24(2),61-65。

    陳光輝、林自強、諶立中(2007)。海洛因成癮者之美沙酮代替療法。台灣醫學, 11(3)。

    李思賢(2005)。藥癮再犯罪成因與心理治療介入的可行性:出監毒癮者之回溯性與前瞻性追蹤研究(一)。行政院衛生署管制藥品管理局科技研究發展計畫
    成果報告。

    李思賢(2006)。藥癮再犯罪成因與心理治療介入的可行性:出監毒癮者之回溯性與前瞻性追蹤研究(二)。行政院衛生署管制藥品管理局科技研究發展計畫
    成果報告。

    李思賢、王榮德、王博恩、王永衛、方啟泰、任全鈞、武維馨、陳耀謙、游錦雲、鄭保志、劉宜廉(2008)。台灣北部地區美沙冬替代療法實施背景、成效及成本效益:三年期追蹤研究(一)。行政院衛生署管制藥品管理局科技研究
    發展計畫成果報告。


    李思賢(2009)。美沙冬替代療法的實施背景與現況。管制藥品簡訊,39。

    俞筱鈞(1994)。瑞文氏標準圖形推理測驗指導手冊。台北市:中國行為科學社。

    黃秀霜(2001)。中文年級認字量表:指導手冊。台北市:心理出版社。

    黃華妮(民99)。利用神經心理作業初探台灣地區海洛因戒治者之認知功能研究。國立政治大學心理系碩士論文。

    傅雅懌(民99)。海洛因藥癮者抑制歷程初探。國立中正大學臨床心理研究所
    碩士論文。

    英文部份

    American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders (4t ed., Text Revision; DSM-IV-TR). Washington, DC, American
    Psychiatric Association.

    Arce, E., & Santisteban, C. (2006).Impulsivity: a review. Psicothema , 18, 213-220.

    Baddeley, A. D. (1986)。 Working memory. New York: Oxford University Press.

    Barnett, P. G., & Hui, S. S. (2000). The Cost-Effectiveness of methadone maintenance. The Mount Sinai journal of Medicine, 67, 365-374.

    Bearre, L., Sturt, P., Bruce, G., & Jones, B. T. (2007). Heroin-related attentional bias and monthly frequency of heroin ue are positively associated in attenders of a
    harm reduction service. Addictive Behaviors, 32, 784-792.

    Bechara, A., Noel, X., & Crone, E. A. (2006). Loss of willpower abnormal neural mechanisms of impulse control and decision making in addiction. Handbook of implicit cognition and addiction . Thousand Oaks CA: SAGE, 215-32.

    Clark, J. M. (1996). Contribution of inhibitory mechanisms to unified theory in neuroscience and psychology. Brain and Cognition, 30, 127-152.

    Cox, W. M., Fadardi, J., & Pothos, E. M. (2006).The Addiction-Stroop Test: Theoretical Considerations and Procedural Recommendations. Psychological Bulletin, 132, 443-476.

    Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology,146, 348-361.

    Field, M., & Cox, W. M. (2008). Attentional bias in addictive behaviors : review of its development, causes, and consequences. Drug and Alcohol Dependence, 97,1-20.

    Fishbein, D. H., Krupitsky, E., Flannery, B. A., Langevin, D. J., Bobashev, G., Verbitskaya, E., Augustine, C.B., Bolla ,K. E., Zvartau, S., B., Egorova, V., Bushara, N., & Tsoy, M. (2007). Neurocognitive characterizations of Russian heroin Addicts without a significant his tory of other drug use. Drug and Alcohol Dependence, 90, 25-38.

    Franken, I. H. A., Kroon, L. Y., Wiers, R. W., & Jansen, A. (2000) Selective cognitive processing of drug cues in heroin dependence. Journal of Psychopharmacology,14 (2), 395-400.

    Friedman, N. P., & Miyake, A. (2004). The relations among inhibition and interference control functions: a latent-variable analysis. Journal of Experimental psychology: General, 133 (1), 101-135.

    Fu L. P., Bi, G. H., Zou, Z. T., Wang, W., Ye, E. M., Ma, L., Fan. M., & Yang, Z.(2008).Impaired response inhibition function in abstinent heroin dependents: An fMRI study. Neuroscience Letters, 438, 322-326.

    Gardini, S., Caffarra, P., & Venneri , A. (2009) Decreased drug-cue-induced attentional bias in individuals with treated and untreated drug dependence. Acta Neuropsychiatrica . (21), 179–185

    Goodman, A. (1990). Addiction: definition and implications. British Journal of Addiction, 85 (11), 1403-1408.

    Johnstone, S. J., Pleffer, C. B., Barry, R, J., Clarke, A, R., & Smith, J, L. (2005).Development of Inhibitory Processing During the Go/NoGo Task:A behavioral and event—related potential study of children and adults. Journal of
    Psychophysiology, 19, 11-23.

    Lezak M.D. (1995). Neuropsychological assessment (3rd ed.). New York, Oxford University Press.

    Loewenstein, G. (1996). Out of control: visceral influences on Behavior.Organizational Behavior and Human Decision Processes.65, 272-292.


    Logan, G. D. (1994). A user’s guide to the stop signal paradigm. In D. Dagenbach & T. H. Carr (EDS.), Inhibitory processes in attention, memory and language (pp. 189-239). San Diego, CA: Academic Press.

    Logan, G. D., & Cowan, W. B. (1984). On the ability to inhibit thought and action: A theory of an act of control. Psychological Review, 91, 295-327.

    Lubman, D. I., Peters L. A., Mogg, K., Bradley, B. P., Deakin, J. F. W. (2000). Attentional bias for drug cues in opiate dependence. Psychol Med ,(30) ,169–175.

    Lyvers, M., & Yakimoff, M. (2003) Neuropsychological correlates of opiod dependence and withdrawal. Addictive Behavior, 28, 605-611

    Marissen, M. A. E., Franken, I. H. A., Waters. A. J., Blanken, P., Van den Brink, W., & Hendriks, V. M. (2006). Attentional bias predicts heroin relapse following treatment. Addiction,(101),1306–1312

    Marsch, L. A. (1998). The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior and criminality: a meta-analysis. Addiction, 93, 515-532.

    Mintzer, M. Z., & Stitzer, M. L. (2002). Cognitive impairment in methadone maintenance patients. Drug and alcohol Dependence, 67, 41-51.

    Mintzer,M. Z., Copersino, M. L., Stitzer, M. L. (2005).Opioid abuse and cognitive performance. Drug and alcohol Dependence, 78, 225-230.

    Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., Swann, A. C. (2001). Psychiatric Aspects of Impulsivity. The American Journal of Psychiatry. 158, 1783 – 1793.

    Moeller, F. G. & Dougherty, D. M.(2002). Impulsivity and substance abuse: What is the connection? Addict Disord Their Treatment, 1, 3-10.

    Murphy, F. C., Sahakian, B. J., Rubinzstein, J. S., et al. (1999) Emotional bias and inhibitory control processes in mania and depression. Psychological Medicine, 29, 1307-1321.

    Newman, J, P., Nathan, S., Widom, C. S. (1985). Passive avoidance in syndromes of disinhibition: Psychopathy and extraversion. Journal of Personality and Social Psychology, 48(5), 1316-1327.

    Nigg, J. T. (2000).On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychological bulletin, 126, 220-246.

    Noel, X., Van der Linden, M., d’Acremont M., Colmant, M., Hanak, C., Pelc, I., Verbanck, P., & Bechara, A. (2005). Cognitive biases toward alcohol-related words and executive deficits in polysubstance abusers with alcoholism. Addiction, 100 (9), 1302-1309.

    Noel, X., Van der Linden, M., d’Acremont, M., Bechara, A., Dan, B., Hanak, C., & Verbanck, P. (2007). Alcohol cues increase impulsivity in individuals with alcoholism. Psychopharmacol, 192, 291-298.

    Passetti, F., Clark, L., Mehta, M. A., Joyce, E., King, M. (2007). Neuropsychological predictors of clinical outcome in opiate addiction. Drug and Alcohol Dependence, 94, 82-91.

    Prosser, J., Cohen, L. J., Steinfeld, M., Eisenberg, D., London, E.D., & Galynker, I. I. (2006). Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug Alcohol Depend, 83(3), 240-247.

    Reynolds, B., Ortengren, A., Richards, J.B., De Wit, H. (2006). Dimension of impulsive Behavior: personality and behavioral measures. Pers. Individual Differences , 40, 305-315.

    Robinson, T. E., & Berridge K. C. (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Research Review, 18, 247-291.

    Robinson, T. E., & Berridge K. C. (2001). Icentive-sensitization and addiction. Addiction, 96, 103-144.

    Robinson, T. E., & Berridge K. C. (2003). Addiction. Annual Review of Psychology, 54, 25-53.

    Snodgrass, J. & Corwin, J. (1988). Pragmatics of measuring recognition memory: applications to dementia and amnesia. Journal of experimental psychology, 117, 34-50.

    Tiffany, S. T. (1990). A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychological Review, 97( 2), 147-168.

    Treisman, A. (1969). Strategies, and models of selective attention . Psychological Review, 76, 282-299.

    Verdejo, A., Toribio, I., Orozco, C., Puente, K. L., & Perez-Garcia, M. (2005). Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug alcohol Depend, 78,283-288.

    Verdejo-Garcia, A., & Perez-Garcia, M.(2007).Profile of executive deficits in cocaine and heroin polysubtance users: common and diferential effects on separate executive components. Psychopharmacology, 190, 517-530.

    Verdejo-Garcia, A. J., Perales, J. C., & Perez-Garcia, M. (2007). Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addictive Behaviors, 32, 950-966.

    Verdejo-Garcia, A., Lawrence, A. J., Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: Review of Findings From high-risk research, problem Gamblers and genetic association studies. Neuroscience and Biobehavioral Reviews, 32, 777-810.

    Verheul, R., Van den Brink, W., Geerlings, P. (1999). A three-pathway psychobiological model of craving of alcohol. Alcohol & Alcoholism, 34(2), 197-222.
    Description: 碩士
    國立政治大學
    心理學研究所
    95752018
    100
    Source URI: http://thesis.lib.nccu.edu.tw/record/#G0095752018
    Data Type: thesis
    Appears in Collections:[心理學系] 學位論文

    Files in This Item:

    File SizeFormat
    201801.pdf843KbAdobe PDF1859View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback