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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/20725


    Title: Acute Effects of d-Amphetamine on the DRL Schedule Behavior in the Rat: Comparison with Selective Dopamine Receptor Antagonists
    Authors: Liao, Ruey-Ming
    廖瑞銘
    Cheng, Ruey-Kuang
    Contributors: 國立政治大學心理學系
    Keywords: D1 and D2 receptors;IRT analysis;ketamine;pentylenetetrazole;psychostimulant;raclopride;SCH23390;timing behavior
    Date: 2005
    Issue Date: 2008-12-31 10:48:03 (UTC+8)
    Abstract: Amphetamine and it analogs have been shown to affect operant behavior maintained on the
    differential reinforcement of a low-rate (DRL) schedule. The aim of the present study was to investigate
    what specific component of the DRL response is affected by d-amphetamine. The acute effects of
    d-amphetamine on a DRL task were compared with those of the selective dopamine D1
    and D2
    receptor
    antagonists, SCH23390 and raclopride, respectively. Pentylenetetrazole and ketamine were also used as
    two reference drugs for comparison with d-amphetamine as a psychostimulant. Rats were trained to
    press a lever for water reinforcement on a DRL 10-s schedule. Acute treatment of d-amphetamine
    (0, 0.5, and 1.0 mg/kg) significantly increased the response rate and decreased the reinforcement in a
    dose-related fashion. It also caused a horizontal leftward shift in the inter-response time (IRT)
    distribution at the doses tested. Such a shifting effect was confirmed by a significant decrease in the peak
    time, while the mean peak rate and burse response remained unaffected. In contrast, both SCH23390
    (0, 0.05, and 0.10 mg/kg) and raclopride (0, 0.2, and 0.4 mg/kg) significantly decreased the total, nonreinforced, and burst responses. The de-burst IRT distributions were flattened out as shown by the doserelated decreases in the mean peak rate for both dopamine antagonists, but no dramatic shift in peak
    time was detected. Interestingly, neither pentylenetetrazole (0, 5, and 10 mg/kg) nor ketamine (0, 1, and
    10 mg/kg) disrupted the DRL behavioral performance. It is then conceivable that d-amphetamine at the
    doses tested affects the temporal regulation of DRL behavior. The effectiveness of d-amphetamine is
    derived from its drug action as a psychostimulant. Taken together, these data suggest that different
    behavioral components of DRL task are differentially sensitive to pharmacological manipulation.
    Relation: Chinese Journal of Physiology, 48(1), 41-50
    Data Type: article
    Appears in Collections:[Department of Psychology] Periodical Articles

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