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    题名: Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists
    作者: Liao, Ruey-Ming
    廖瑞銘
    贡献者: 國立政治大學心理學系
    关键词: Nucleus accumbens;Dopamine receptor subtypes;SCH23390;Raclopride;Drug reward;Place conditioning
    日期: 2008-03
    上传时间: 2008-12-29 15:34:23 (UTC+8)
    摘要: The present study investigated the role of dopamine receptors within the nucleus accumbens in place conditioning induced by D-amphetamine. Previous work has shown that conditioned place preference can be established by intra-accumbens infusion of amphetamine. The present study further examined whether bilateral co-infusion of the selective dopamine receptor antagonists with D-amphetamine into this region would disrupt the development of conditioned place preference induced by intra-accumbens amphetamine treatment. Bilateral infusions of D-amphetamine into the nucleus accumbens at the dose of 10 microg per side significantly induced conditioned place preference. At the tested doses of 1 microg and 10 microg, either the selective D1 dopamine receptor antagonist (SCH23390) or the selective D2 dopamine receptor antagonist (raclopride) infused with the high dose into the nucleus accumbens significantly blocked the development of conditioned place preference induced by intra-accumbens amphetamine treatment. Furthermore, the sole infusion of SCH23390 or raclopride into the nucleus accumbens produced little or no place conditioning effect. It is concluded that the dopamine D1 and D2 receptors in the nucleus accumbens are critically involved in the development of amphetamine induced conditioned place preference.
    關聯: Pharmacology, Biochemistry and Behavior, 89(3), 367-373
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1016/j.pbb.2008.01.009
    DOI: 10.1016/j.pbb.2008.01.009
    显示于类别:[心理學系] 期刊論文

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