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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/120070
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/120070


    Title: Antipsychotic drugs and risk of newly diagnosed tuberculosis in schizophrenia
    Authors: Liu, Hsing‐Cheng;Hung, Galen Chin‐Lun;Yang, Shu‐Yu;Liao, Ya‐Tang;Pan, Chun‐Hung;Chen, Chiao‐Chicy;Kuo, Chian‐Jue
    潘俊宏
    Pan, Chun-Hung
    Contributors: 心理系
    Keywords: antipsychotics;clozapine;schizophrenia;tuberculosis
    Date: 2018-10
    Issue Date: 2018-09-11 18:31:33 (UTC+8)
    Abstract: Aim : Patients with schizophrenia have a higher incidence of tuberculosis than do people in the general population. Information is limited regarding the association between antipsychotic agents and the risk of tuberculosis in patients with schizophrenia. This exploratory study assessed the risk of tuberculosis among patients with schizophrenia on antipsychotic therapy. Methods : Among a nationwide schizophrenia cohort derived from the National Health Insurance Research Database in Taiwan (n = 32 399), we identified 284 patients who had developed newly diagnosed tuberculosis after their first psychiatric admission. Ten or fewer matched controls were selected randomly from the cohort for each patient based on risk‐set sampling. We categorized exposure to antipsychotic medications by type and defined daily dose. Using multivariate methods, we explored individual antipsychotic agents for the risk of tuberculosis and employed a propensity‐scoring method in sensitivity analyses to validate any associations. Results : Among the antipsychotic agents studied and after adjustment for covariates, current use of clozapine was the only antipsychotic agent associated with a 63% increased risk of tuberculosis (adjusted risk ratio = 1.63, P = 0.014). In addition, the association did not show a clear dose‐dependent relationship. Clozapine combined with other antipsychotic agents showed a potential synergistic risk for tuberculosis (adjusted risk ratio = 2.30, P = 0.044). Conclusion : This exploratory study suggests the potential risk of clozapine on the risk of tuberculosis, especially for those on clozapine in combination with other antipsychotics. Future studies are needed to verify the association.
    Relation: PSYCHIATRY AND CLINICAL NEUROSCIENCES, 72(10), 789-800
    Data Type: article
    DOI 連結: https://doi.org/10.1111/pcn.12736
    DOI: 10.1111/pcn.12736
    Appears in Collections:[心理學系] 期刊論文

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