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    題名: Modular patterning of structure and function of the striatum by retinoid receptor signaling
    作者: 廖文霖
    Liao, Wen-Lin
    Tsai, Hsiu-Chao
    Wang, Hsiao-Fang
    Chang, Josephine
    Lu, Kuan-Ming
    Wu, Hsiao-Lin
    Lee, Yi-Chao
    貢獻者: 神科所
    關鍵詞: basal ganglia;cell proliferation;retinoic acid;stereotypic behavior
    日期: 2008-05
    上傳時間: 2018-05-21 17:38:02 (UTC+8)
    摘要: Retinoid signaling plays a crucial role in patterning rhombomeres in the hindbrain and motor neurons in the spinal cord during development. A fundamentally interesting question is whether retinoids can pattern functional organization in the forebrain that generates a high order of cognitive behavior. The striatum contains a compartmental structure of striosome (or “patch”) and intervening matrix. How this highly complex mosaic design is patterned by the genetic programs during development remains elusive. We report a developmental mechanism by which retinoid receptor signaling controls compartmental formation in the striatum. We analyzed RARβ−/− mutant mice and found a selective loss of striosomal compartmentalization in the rostral mutant striatum. The loss of RARβ signaling in the mutant mice resulted in reduction of cyclin E2, a cell cycle protein regulating transition from G1 to S phase, and also reduction of the proneural gene Mash1, which led to defective neurogenesis of late-born striosomal cells. Importantly, during striatal neurogenesis, endogenous levels of retinoic acid were spatiotemporally regulated such that transduction of high levels of retinoic acid through RARβ selectively expanded the population of late-born striosomal progenitors, which evolved into a highly elaborate compartment in the rostral striatum. RARβ−/− mutant mice, which lacked such enlarged compartment, displayed complex alternations of dopamine agonist-induced stereotypic motor behavior, including exaggeration of head bobbing movement and reduction of rearing activity. RARβ signaling thus plays a crucial role in setting up striatal compartments that may engage in neural circuits of psychomotor control.
    關聯: Proc Natl Acad Sci USA, Vol.105, No.18, pp.6765-6770
    資料類型: article
    DOI: https://doi.org/10.1073/pnas.0802109105
    顯示於類別:[神經科學研究所 ] 期刊論文

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