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    題名: Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia.
    作者: 藍亭
    Martino, Matteo
    Magioncalda, Paola
    Yu, Hua
    Li, Xiaojing
    Wang, Qiang
    Meng, Yajing
    Deng, Wei
    Li, Yinfei
    Li, Mingli
    Ma, Xiaohong
    Lane, Timothy
    Duncan, Niall W.
    Northoff, Georg
    Li, Tao
    貢獻者: 心理學系
    關鍵詞: schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization
    日期: 2018-02
    上傳時間: 2018-01-15 11:39:34 (UTC+8)
    摘要: Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity.
    關聯: Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1093/schbul/sbx067
    DOI: 10.1093/schbul/sbx067
    顯示於類別:[心理學系] 期刊論文

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