English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 78486/108082 (73%)
造訪人次 : 20279152      線上人數 : 463
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/114852
    請使用永久網址來引用或連結此文件: http://nccur.lib.nccu.edu.tw/handle/140.119/114852


    題名: Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants
    作者: 林志陵
    Lin, Chih-Lin
    Kao, Jia-Horng
    貢獻者: 心理系
    關鍵詞: Chronic hepatitis B;Hepatitis B virus (HBV);Genotype;HBV mutant;Cirrhosis;Hepatocellular carcinoma
    日期: 2017-06
    上傳時間: 2017-11-22 15:45:57 (UTC+8)
    摘要: Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice.
    關聯: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 3, Pages 249-255
    資料類型: article
    DOI: https://doi.org/10.1016/j.bpg.2017.04.010
    顯示於類別:[心理學系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    249255.pdf550KbAdobe PDF71檢視/開啟


    在政大典藏中所有的資料項目都受到原著作權保護.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋