English  |  正體中文  |  简体中文  |  Post-Print筆數 : 11 |  Items with full text/Total items : 88657/118248 (75%)
Visitors : 23503916      Online Users : 237
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/113036
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/113036


    Title: Antipsychotic reexposure and recurrent pneumonia in schizophrenia: A nested case-control study
    Authors: 潘俊宏
    Hung, Galen Chin Lun
    Liu, Hsing Cheng
    Yang, Shu Yu
    Pan, Chun Hung
    Liao, Ya Tang
    Chen, Chiao Chicy
    Kuo, Chian Jue
    Contributors: 心理系
    Keywords: amisulpride;antidepressant agent;aripiprazole;benzodiazepine;chlorpromazine;clozapine;flupentixol;haloperidol;mood stabilizer;neuroleptic agent;olanzapine;quetiapine;risperidone;sulpiride;zotepine;clozapine;neuroleptic agent;adult;Article;case control study;cohort analysis;controlled study;disease association;disease classification;drug efficacy;drug reexposure;drug safety;female;high risk patient;human;major clinical study;male;pneumonia;priority journal;propensity score;recurrent disease;recurrent pneumonia;recurrent pneumonia;schizophrenia;Taiwan;treatment duration;adolescent;aged;chemically induced;complication;dose response;factual database;middle aged;pneumonia;risk factor;schizophrenia;sexual development;young adult;Adolescent;Adult;Aged;Antipsychotic Agents;Case-Control Studies;Clozapine;Databases, Factual;Dose-Response Relationship, Drug;Female;Humans;Male;Middle Aged;Pneumonia;Recurrence;Risk Factors;Schizophrenia;Sex Characteristics;Young Adult
    Date: 2016-01
    Issue Date: 2017-09-15 15:19:34 (UTC+8)
    Abstract: Objective: Few studies have used systematic datasets to assess the safety of antipsychotic rechallenge after an adverse event. This nested case-control study estimated the risk for recurrent pneumonia after reexposure to antipsychotic treatment. Method: In a nationwide schizophrenia (ICD-9-CM code 295) cohort (derived from the National Health Insurance Research Database in Taiwan) who were hospitalized for pneumonia (ICD-9-CM codes 480-486, 507) between 2000 and 2008 (N = 2,201), we identified 494 subjects that developed recurrent pneumonia after a baseline pneumonia episode. Based on risk-set sampling in a 1:3 ratio, 1,438 matched controls were selected from the cohort. Exposures to antipsychotics were categorized by type, duration, and defined daily dose. Using propensity score-adjusted analysis, we assessed individual antipsychotics for the risk of recurrent pneumonia; we furthermore assessed the effect of reexposure to these antipsychotics on the risk of recurrent pneumonia. Results: Of the antipsychotics studied, current use of clozapine was the only one associated with a clear dose-dependent increase in the risk for recurrent pneumonia (adjusted risk ratio = 1.40, P =.024). Intriguingly, patients reexposed to clozapine had a higher risk for recurrent pneumonia (adjusted risk ratio = 1.99, P =.023) than those receiving clozapine only prior to the baseline pneumonia, and this risk was associated with gender. Women reexposed to clozapine were more susceptible to recurrent pneumonia (adjusted risk ratio = 4.93, P =.050). Conclusions: In patients experiencing pneumonia while undergoing clozapine treatment, physicians should carefully consider the increased risk of pneumonia recurrence when clozapine is reintroduced. Future studies should try to quantify the risk of other medical conditions associated with clozapine reexposure.
    Relation: Journal of Clinical Psychiatry, 77(1), 60-66
    Data Type: article
    DOI 連結: http://dx.doi.org/10.4088/JCP.14m09301
    DOI: 10.4088/JCP.14m09301
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML289View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback