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    題名: Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania
    作者: Martino, Matteo
    Magioncalda, Paola
    Huang, Zi Rui
    Conio, Benedetta
    Piaggio, Niccolò
    Northoff, Georg
    貢獻者: 心智、大腦與學習研究中心
    關鍵詞: anterior cingulate;bipolar depression;BOLD signal;cingulate gyrus;clinical article;conference;controlled study;default mode network;electroencephalogram;follow up;Hamilton Depression Rating Scale;human;inferior parietal lobule;mania;medial prefrontal cortex;middle frontal gyrus;middle temporal gyrus;nerve cell network;neuroimaging;postcentral gyrus;posterior cingulate;potential difference;priority journal;replication study;resting state network;sensorimotor function;Young Mania Rating Scale;adolescent;adult;affect;bipolar disorder;blood;brain mapping;comparative study;female;male;middle aged;movement (physiology);nerve cell network;nuclear magnetic resonance imaging;pathophysiology;physiology;psychology;rest;restlessness;sensation;thinking;young adult;oxygen;Adolescent;Adult;Affect;Bipolar Disorder;Brain Mapping;Female;Humans;Magnetic Resonance Imaging;Male;Middle Aged;Movement;Nerve Net;Oxygen;Psychomotor Agitation;Rest;Sensation;Thinking;Young Adult
    日期: 2016-04
    上傳時間: 2017-08-31 15:00:01 (UTC+8)
    摘要: Depressive and manic phases in bipolar disorder show opposite constellations of affective, cognitive, and psychomotor symptoms. At a neural level, these may be related to topographical disbalance between large-scale networks, such as the default mode network (DMN) and sensorimotor network (SMN). We investigated topographical patterns of variability in the resting-state signal-measured by fractional SD (fSD) of the BOLD signal-of the DMN and SMN (and other networks) in two frequency bands (Slow5 and Slow4) with their ratio and clinical correlations in depressed (n = 20), manic (n = 20), euthymic (n = 20) patients, and healthy controls (n = 40). After controlling for global signal changes, the topographical balance between the DMN and SMN, specifically in the lowest frequency band, as calculated by the Slow5 fSD DMN/SMN ratio, was significantly increased in depression, whereas the same ratio was significantly decreased in mania. Additionally, Slow5 variability was increased in the DMN and decreased in the SMN in depressed patients, whereas the opposite topographical pattern was observed in mania. Finally, the Slow5 fSD DMN/SMN ratio correlated positively with clinical scores of depressive symptoms and negatively with those of mania. Results were replicated in a smaller independent bipolar disorder sample.We demonstrated topographical abnormalities in frequency- specific resting-state variability in the balance between DMN and SMN with opposing patterns in depression and mania. The Slow5 DMN/SMN ratio was tilted toward the DMN in depression but was shifted toward the SMN in mania. The Slow5 fSD DMN/SMN pattern could constitute a state-biomarker in diagnosis and therapy.
    關聯: Proceedings of the National Academy of Sciences of the United States of America, 113(17), 4824-4829
    資料類型: conference
    DOI: http://dx.doi.org/10.1073/pnas.1517558113
    顯示於類別:[心智‧大腦與學習研究中心 ] 會議論文

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