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    題名: Abnormal functional–structural cingulum connectivity in mania: combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder
    作者: Martino, Matteo
    Magioncalda, Paola
    Saiote, Catarina
    Conio, Benedetta
    Escelsior, Andrea
    Rocchi, Giulio
    Piaggio, Niccolò
    Marozzi, Valentina
    Huang, Zirui
    Ferri, Francesca
    Amore, Mario
    Inglese, Matilde
    Northoff, Georg
    貢獻者: 心智、大腦與學習研究中心
    日期: 2016-10
    上傳時間: 2017-08-31 11:23:33 (UTC+8)
    摘要: Objective: The objective of the study was to investigate the relationship between structural connectivity (SC) and functional connectivity (FC) in the cingulum in bipolar disorder (BD) and its various phases. Method: We combined resting-state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate FC and SC of the cingulum and its portions, the SC–FC relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic (n = 21), depressed (n = 20), and euthymic (n = 20) bipolar patients and healthy controls (HC) (n = 42). Results: First, we found decreased FC between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and HC. Second, we observed decreased SC of the cingulum bundle, particularly in its anterior part, in manic patients when compared to HC. Finally, alterations in the cingulum FC (but not SC) correlated with clinical severity scores while changes in the cingulum SC (but not FC) were related with neurocognitive deficits in sustained attention in BD. Conclusion: We demonstrate for the first time a reduction in FC and concomitantly in SC of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in BD. This supports the central role of cingulum connectivity specifically in mania.
    關聯: Acta Psychiatrica Scandinavica, 134(4), 339-349
    資料類型: article
    DOI: http://dx.doi.org/10.1111/acps.12596
    顯示於類別:[心智‧大腦與學習研究中心 ] 期刊論文

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